Side Effects of NSAIDs in Pets

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Side Effects of NSAIDs in Pets

NSAIDS for dogsIf you receive the Healthy Happy Dogs newsletter, or have been reading my sites for any length of time, you will know that I am very wary of giving my dogs any type of drugs without careful consideration.  (Of course, occasionally there is no choice, but more often there is).

On the question of NSAIDS for dogs, you may have read my articles on Rimadyl for Dogs – and specifically the dangers associated with giving these drugs.

Following is an article by Ashley Mitek from VetMed. And please note that this is a conventional veterinary view, so any holistic vet would be a lot more circumspect and cautious about these drugs. …

Here is the article:

 Pets More Susceptible to Side Effects of NSAIDs

It is now widely accepted in human medicine that one of the largest causes of liver failure (and also liver transplant surgery) in the United States is due to the overuse of a particular type of non-steroidal anti-inflammatory drug (NSAID) named acetaminophen. This stunning research finding was first published in the December 2005 issue of the journal Hepatology. Nearly every person in the country has used one type of NSAID or another, whether that be ibuprofen, naproxen, or aspirin. When taken correctly, these drugs have very few side effects.

However, “the use of NSAIDS is one of the most controversial topics in veterinary medicine,” says Dr. Stuart Clark-Price, a veterinary anesthesiologist and internal medicine specialist at the University of Illinois Veterinary Teaching Hospital in Urbana. As many pill-popping humans can attest, these drugs have great anti-inflammatory, anti-fever, and pain relief properties because they inhibit certain enzymes in the body. If these drugs have such great properties, then why is their use so controversial in animals, one may ask?

NSAIDS for dogs“Cats and dogs are much more susceptible than people to the adverse effect of NSAIDs,” explains Dr. Clark-Price. In short, dogs and cats are not simply smaller versions of people. They lack certain enzymes that we have, and also may process these drugs differently. In short, the use of NSAIDS in dogs and cats comes with a smaller safety margin. Because of this, it is critical that veterinary patients be accurately dosed and routinely monitored for side effects.

Despite of the increased risk, NSAIDS are frequently used in veterinary patients with minimal adverse effects. For example, in a routine spay or castration in a healthy dog or cat over the age of the age of 6 weeks, NSAIDS are a good choice for pain relief.  Because there will be mild to moderate inflammation in these instances, which is exactly what these drugs work to prevent, “NSAIDS are probably better for consistent pain control in cases of inflammation than even opioids,” notes Dr. Clark-Price.

Another reason dogs are prescribed NSAIDs is due to chronic arthritis. For example, an older Labrador that has a hard time getting up in the morning due to joint pain may be given a certain NSAID daily. But careful monitoring is critical in these patients.  The most common complication is gastro-intestinal tract ulceration.  This can be a minor problem, but it can also progress to life threatening perforations.

Other problems that can develop are kidney and liver dysfunction, or blood abnormalities such as the decreased ability to clot. Because liver and kidney disease are potential side effects of NSAIDs, it is important that a dog starting on a course of these drugs have its blood tested frequently to determine if kidney and liver function are starting to decrease. If so, it is imperative that NSAID use be terminated.

Symptoms owners should watch for while their pet is on NSAIDS include: NSAIDS for dogs

  • Decreased appetite
  • Lethargy or other changes in behavior
  • Vomiting or diarrhea
  • Yellowing of the skin, whites of the eye, or gums
  • Skin redness or scabs

For more information on the risks of NSAID use in pets please talk to your local veterinarian or visit the American Veterinary Medical Association’s Web site on the topic at .

Please do not give any NSAIDs to your pet without first contacting your veterinarian. For example, one acetaminophen (Tylenol) pill may kill a cat.

An archive of Pet Columns from the University of Illinois College of Veterinary Medicine is available online at .

Veterinary Extension/Office of Public Engagement

University of Illinois College of Veterinary Medicine


Source: Stuart Clark-Price, DVM, MS, DACVIM, DACVA ”

And again, if you are interested in learning more about the dangers of NSAIDs in pets, and some natural alternatives – particularly if the issue is an arthritic or related condition, go to – Natural Arthritis Treatment for Dogs.

There are alternatives to using NSAIDs.  Be guided by your vet, but always make your own decisions for your dog once you have all the facts.

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